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A 2003 review by Khavinson in Neuro Endocrinology Letters covering pineal and thymic peptide bioregulators and their reported longevity effects: No bioregulator peptide has completed a large randomised controlled trial meeting ICH GCP standards with independent oversight

Free Radic Biol Med 41:10791091 Liang JH, Li YN, Qi JS, Jia XX (2010) Peroxynitrite-induced protein nitration is responsible for renal mitochondrial damage in diabetic rat

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One human trial found 3 g/m2 intravenous glutathione given 20 minutes prior to cisplatin (100 mg/m2) led to a significant reduction in nephrotoxicity in patients with ovarian cancer compared with those receiving cisplatin alone

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(Context for long-term GH/IGF-1 elevation risks.) U.S